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SIRPG encodes SIRPγ, a member of the signal regulatory protein (SIRP) family ( SIRPG produces multiple transcript isoforms via alternative splicing, with isoform 1 being the most expressed in CD4+ and CD8+ T cells ( SIRPG knockout in Jurkat T cells resulted in fewer T cell conjugates, which suggests a role in T cell to T cell interactions ( in vivo with a reduced memory T cell pool