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With the development of molecular techniques that allow the cloning and characterization of the human GHR, the pathophysiology of GHI has been better understood ( The purpose of this review is to describe the common genetic abnormalities related to the spectrum of GHI, focusing on those determining IGF-1 deficiency in order to better clarify each single entity of this complex group and to promote a tailored approach based on genetic features

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But despite their explosive demand, GLP-1s have their share of drawbacks