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We already know that Hcy can induce ROS accumulation and generate oxidative stress, which can enhance the oxidation of LDL to promote AS (121)

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Interestingly, the excessive uptake of neuronal α-synuclein by astrocytes can lead to accumulation of aggregates of this protein in astrocytes, and cause an upregulation of IL-1 α, IL-1β and IL-6, followed by the release of TNF-α and IL-6 [6]

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