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Mitochondria not only promote ferroptosis via generation of ROS but also appear to inhibit it through consuming glutamate, counteracting the suppressive influence from elevated extracellular glutamate upon the Xc system [74]

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Pretreatment with the stem bark of the Betulaceae plant Alnus japonica (Thunb.) Steud., a common folk medicine for cancer and hepatitis indigenous to Korea, revealed dose-dependent antioxidant effects in APAP-associated hepatotoxicity (Tadashi et al., 1990)