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A growing body of evidence is highlighting the pivotal role played by adventitial cells in blood vessel remodeling and the maintenance of vascular homeostasis ( 5.1 Role of vascular endothelial cell senescence in vascular calcification VECs adeptly sense a myriad of stimuli coursing through the bloodstream and promptly respond, upholding vascular equilibrium via autocrine or paracrine mechanisms

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Even so, the combination provides a well-characterized experimental framework for connecting pulsatile pituitary output to peripheral tissue remodeling responses