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Six middle-aged patients with documented chronic sleep disturbance received a single intravenous dose of synthetic DSIP at 25 nmoles/kg body weight

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Specifically, SIRT1 deacetylates autophagy-related proteins, such as Atg5, Atg7, and LC3, thereby facilitating autophagosome formation and enhancing lipophagy — the selective degradation of lipid droplets that reduces triglyceride accumulation (Lee et al