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Tolerability of tirzepatide was generally improved with a longer dose-escalation period, but the frequency of participants experiencing any adverse effects remained high (77–82% in the SURMOUNT trials), and an even higher frequency of AEs among participants with T2D of up to 95% was reported in an Asian-Pacific population with a lower mean body weight in the SURPASS-AP-combo trial

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Sterile technique protects against infection