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Nrf2, a member of the “cap’n’collar” family of basic region–leucine zipper transcription factors involved in transcription of antioxidant genes in response to xenobiotic stress, is also a critical regulator of cellular oxidative stress in sepsis (Kolls, 2006) and a regulator of exacerbated proinflammatory cytokine release (cytokine storm) and loss of T lymphocytes (leukopenia) that characterize the most aggressive presentation of SARS-CoV-2-mediated COVID-19 infection (Kobayashi et al., 2016
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Assessment of reactivity of 2 and TRi-1 with N-Boc protected methyl ester of L-selenocysteine Dimethyl bis( N - tert -butoxycarbonyl)-L-selenocystine was synthesized as reported previously 85
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