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Advanced techniques, including de novo synthesis, proteomic analysis, and bioinformatics, further aid in their design, optimization, and functional characterization

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Lipoic acid might be able to increase glutathione synthesis in aged rats by up-regulating the expression of γ-glutamylcysteine ligase (γ-GCL), the rate-limiting enzyme in glutathione synthesis (31), and by increasing cellular uptake of cysteine, an amino acid required for glutathione synthesis (32)