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Pro-C3, a serum biomarker of hepatic fibrogenesis (active scar formation), showed significant reductions, suggesting that survodutide was not just resolving steatohepatitis but also slowing the fibrotic process that ultimately leads to cirrhosis and liver failure

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Studies Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging – Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders – The senescence-associated secretory phenotype: the dark side of tumor suppression – FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice – Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes – FOXO4 peptide targets myofibroblast ameliorates bleomycin-induced pulmonary fibrosis in mice through ECM-receptor interaction pathway – FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells – FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway –