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Reducing injection site reactions: - Let the reconstituted solution reach room temperature before injecting (2 to 3 minutes out of the fridge) - Inject slowly (3 to 5 seconds) - Use the thinnest needle available (31 gauge) - Rotate sites religiously - Let alcohol dry completely before puncturing If you experience persistent redness, warmth, or swelling that expands beyond 5 cm from the injection site, or if you develop fever, contact your healthcare provider immediately