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Therefore, we defend stable gastric pentadecapeptide BPC 157 therapy’s efficacy and pleiotropic beneficial effects, along with its high safety (LD1 not achieved), against speculation of its negative impact, speculation of angiogenesis toward tumorigenesis, increased NO and eNOS, damaging free radical formation, and neurodegenerative diseases (Parkinson’s disease and Alzheimer’s disease)

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The safety picture changes with route of administration researchers and regulatory bodies distinguish sharply between topical cosmetic use, which has a substantial safety record, and non-FDA-approved injectable preparations, where contamination, sterility, and product-identity risks are independent concerns tied to manufacturing quality rather than to GHK-Cu itself