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MT1 vs MT2: The Key Differences MT1 (Afamelanotide): Selective MC1R agonist Primarily tanning effects Minimal appetite suppression Minimal sexual effects Generally better side effect profile Shorter half-life (requires more frequent dosing) Actually FDA approved in Europe and Australia for specific conditions More expensive per dose MT2: Non-selective melanocortin agonist Tanning + appetite suppression + sexual effects More side effects (nausea, flushing) Longer half-life (less frequent dosing) Not FDA approved anywhere Cheaper per dose More “bang for your buck” if you want multiple effects The Effects People Actually Experience Tanning: This is what MT1 does, and it does it well

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