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ESCs are derived from epiblast of the blastocyst from which many tissues of embryo arise, whereas ASCs are localized in adult organs [Table 2] where these cells function to replace damaged cells during tissue regeneration.[26,27] SCs are further classified into four types based on their transdifferentiation potential which include – totipotent, pluripotent, multipotent and unipotent SC.[24] ESCs are known to have totipotent and pluripotent in nature and have the ability to differentiate into cells of three germ layers – endoderm, mesoderm and ectoderm.[28] ASC is multipotent and can give rise to differentiated cells of anyone germ layer.[29] Unipotent SCs arise from multipotent cells and are dedicated to differentiate into specific type of tissue, for example, precursors for cardiomyocytes present in human heart or satellite cells characteristic for skeletal muscles are dedicated to differentiate into specific tissue.[30] Table 2
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Given the ability of tesofensine to modulate the activity of the LH, our preclinical findings agree with the proposal that tesofensine could be a useful treatment for patients with hypothalamic obesity, a rare feeding disorder, as recently demonstrated [38]
