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Our later studies on the Shank3 -/- and Cntnap2 -/- knockout mice, the human SH-SY5Y cell line, and the human induced pluripotent stem cells‐derived cortical neurons isolated from patients carrying a SHANK3 mutation confirmed the increased levels of NO and protein SNO [172,173,174,175,176]

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Research comparing MC4R agonism — the mechanism melanotan 2 activates for libido effects — has been more extensively studied through bremelanotide (PT-141), which is a related compound