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Nrf2-dependent antioxidant pathway Allicin was also found to upregulate the expression of glutamate-cysteine ligase (GCL), the rate-limiting enzyme in glutathione synthesis, and other Phase II detoxifying/antioxidant enzymes, likely via the activation of the nuclear factor E2-related factor 2 (Nrf2)-dependent pathway (19)

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GLP-1 Receptor Agonists GLP-1 receptor agonists like semaglutide and dual GIP/GLP-1 agonists like tirzepatide represent the most evidence-based pharmacological tools currently available for weight management